Abstract: The development status of sulfur-containing reagents is introduced, and systematically summarizes the leaching mechanism and application of four sulfur-containing non-cyanide reagents such as thiourea, thiosulfate, thiocyanate and stone sulfur.Sulfur immersion gold reagent has the advantages of non-toxic or low toxicity, strong adaptability to impurity elements such as arsenic, carbon and copper, and high leaching efficiency.The leaching effect and adaptability of sulfur-containing reagents to different types of refractory gold ore are analyzed.It is of guiding significance for the clean and efficient development of refractory gold mines and the construction of green and environmentally friendly mines.