Abstract: The main useful elements in a copper lead, zinc and silver polymetallic ore are copper, lead and zinc, and the associated elements are silver, cadmium and bismuth.Copper, lead and zinc were recovered by “partial bulk flotation-floating copper and lead depressing zinc-separation of copper and lead process”.The grade and recovery rate of copper concentrate are Cu 29.22% and 88.87%, respectively.The grade and recovery of lead concentrate are Pb 55.50% and 85.89%, respectively, and the zinc concentrate grade and recovery rate are Zn 50.35% and 79.35%, respectively.The silver bismuth is mainly concentrated in copper concentrate and lead concentrate, and cadmium is mainly concentrated in zinc concentrate.In this experiment, the three main elements are effectively separated and qualified products are obtained.At the same time, the associated elements are comprehensively recovered and the indicators are ideal, which provided technical support for the development and utilization of the mine.