Abstract: In order to solve the frequent occurrence of spontaneous combustion in high-sulfur coal seam, the cause of multisulfides production in the underground and their influence on spontaneous combustion of coal were analyzed.The 3 stages of spontaneous combustion of sulfur bearing coal were divided according to the burning point of sulfide and the process of coal oxidation and heating.The comprehensive prevention and control technology of spontaneous combustion of different sulfide coal seams was determined.The results show that the spontaneous combustion of high sulfur coal is mainly caused by spontaneous combustion of sulfide.The reliable prediction and prediction should be based on the ignition temperature of sulfide.To prevent and extinguish fire in the coal bed containing pyrite (FeS₂), we should try to control the dryness of the surrounding environment or to pour the inhibitor with limestone and sodium silicate as main materials.In order to prevent and extinguish the coal seam with FeS, the metal products should be recovered in time, and the combined air leakage of the well up and down should be strengthened.It is used to prevent and extinguish fire for coal seam with H₂S by the way of monitor, dilution, spray, injection and pumping.The research results have important guiding significance for preventing and extinguishing fire in high-sulfur coal seam.