Abstract: The response characteristics of blasting vibration to slope in alpine region are seldom analyzed.In order to study the attenuation law of blasting vibration and the response characteristics of slope in alpine region, rock samples in mining area are selected to carry out rock wave impedance test at -25℃ and +20℃, respectively.Blasting vibration monitoring tests are carried out at different temperatures, and then comparative of response characteristics of slope at different temperatures is analyzed based on numerical simulation.The results show that the wave impedance of rock specimens increases by 28.5% at -25℃, and the settlement displacement at the bottom of slope increases with the decrease of temperature under blasting loading, mainly because the attenuation rate of blasting vibration decreases and the action time of seismic wave on slope is prolonged.The research results can provide some guidances for controlling the harmful effect of blasting vibration on slope in the later stage.