Abstract: In order to select the best mining method suitable for a gold mine in Guizhou province, and to solve the problems of difficult mining and high mining cost, according to the actual geological conditions of the mine and through consulting the data, the mining method suitable for the ore body is selected.Combining numerical simulation with unascertained measurement theory, the safety of three alternative mining methods is analyzed by numerical simulation, which is used as the index of optimization model.Combining with mine practical experience, 11 indexes affecting the selection of mining methods, such as stope production capacity, are selected.The objective weights of each index are calculated by using information entropy, and the confidence recognition criteria are introduced for evaluation.At the same time, the mining method optimization model based on unascertained measure theory is constructed by ranking according to superiority degree.Through the comprehensive comparative analysis, the best mining method, i.e.downward mid-deep hole mining and subsequent filling method, is finally determined.This method can effectively solve the problems encountered in current mining, expand the production capacity of mines, reduce mining costs and improve the economic benefits of mines.