Abstract: In addition to the freezing and thawing cycle, the slope in the high-altitude alpine mine will be affected by long-term disturbance caused by blasting mining and large-scale machinery construction and operation, resulting in the failure of slope stability.Through the summary of a great deal of researches on the of mine slope stability at home and abroad, this paper analyzes two shortcomings of the previous researches.One is that most of the researches focus on the normal slope at normal temperature and pressure, there are few studies on the slope stability in low pressure cold region with high altitude.Another is that the study of slope stability under mining disturbance is incomplete.So, this paper based on the engineering background of the east slope of Beizhan iron mine in Hejing county, Xinjiang province, based on the existing slope stability research, the freezing and thawing factors affecting the stability of the slope in the cold region were innovatively introduced.By using analytic hierarchy process (AHP), the 12 factors affecting slope stability and their weight are summarized, and then the corresponding grade of slope stability in cold region is calculated by using fuzzy comprehensive evaluation method.The calculation results show that according to the principle of maximum membership degree in fuzzy comprehensive evaluation, the maximum value of target layer matrix B is 0.64, the corresponding stability level of cold slope is level Ⅲ.