Abstract: The transformation of resource-based cities is facing many difficulties, and reform and innovation is the most effective means to help the transformation of resource-based cities.Resource based cities urgently need some effective stimulation to enhance the innovation power of cities.This paper constructs a dynamic model of innovation system of resource-based cities, simulates and expounds the influence mechanism and sensitivity of government service level, innovation consciousness, education emphasis, urban legal environment, innovation subject's foreign exchange degree and other factors on urban innovation power.The results show that the government's innovation consciousness, service level, education emphasis, legal maturity and foreign exchange level have a positive impact on the city's innovation power.The most sensitive factor is the government's innovation consciousness, followed by the foreign exchange level, and then the legal maturity and government service level, and the impact of education investment is relatively slow.Based on this, this paper puts forward some suggestions and measures to promote the innovation power of cities.At the same time, the conclusion that the economic development of resource-based cities depends on the city's natural conditions gradually decreases under the condition of innovation driven maturity are drawn, which confirms the conditional resource curse theory that the relationship between resource industry dependence and economic development efficiency presents an inverted U-shaped curve.