Abstract: The open-pit mining of non-ferrous metal mines has caused environmental problems such as high and steep slopes and soil acidification, which is the main technical difficulty in ecological restoration. Taking the acid open-pit mining slopes of Zijinshan Gold-Copper Mine in Fujian as the study object, through the field investigations and soil sample analysis, the control method of slope acidification is studied. The mining area includes all kinds of slopes composed of bare rock on the end boundary, rock and soil mixture in the dump and residue produced in the mineral processing process. Two kinds of oxygen barrier covering acidification control methods have been developed, one is invented with 35%-45% sandy soil, 5%-10% calcium oxide, 10%-20% cement, 150-200 g potassium polyacrylate, 20-60 kg organic chelating agent for 1 m³ of material; the other is prepared by 80%-90% neutralizing slag, 5%-10% microbial fertilizer and 1%-5% organic fertilizer for 1 m³ of material. The results of the engineering practice performance show that the pH value of the surface soil has increased from 2.78-5.05 to 8.21-8.56, and the average content of sulfur has decreased by 70%, the soil acidification has been controlled effectively, and the three-dimensional plant community have restored gradually. The study provides the industrial practice demonstration for the ecological restoration and treatment of the open-pit end boundary in non-ferrous metal mines.