The salt lake resources in Qaidam Basin boasts important strategic significance in ensuring China’s food security and bolstering the development of new energy and new material industry.In order to implement Xi Jinping’s major requirement of accelerating the development of a world-class salt lake industrial base, and to take the road of sustainable development, which have put forward higher demands for enhancing guarantee capability of salt lake resources.Based on the data of retained reserves of salt lake resources in Qaidam Basin, adopt the calculation approach of static guarantee period, this paper analyzes guarantee degree through comprehensive research.By taking issue-oriented for guarantee of salt lakes resources in Qaidam Basin and demand-oriented for salt lakes resources to bolster the development of a world-class salt lake industrial base, the research explored implementation paths of ensuring sustainable reserve of salt lakes resources.The study reveales that only the guarantee degree of magnesium and sodium resources in Qaidam Basin are very high, the guarantee degree of potash, lithium and boron resources are medium and low, and the problem of ensuring the guarantee degree of salt lake resources is prominent.The research proposed implementation paths from three aspects in order to promote guarantee capability and sustainable reserve capability of salt lakes resources, such as speed up in place of resource selection and evaluation, strengthen the comprehensive efficient utilization of salt lake resources, perfect the system of salt lake resources protection, utilization and reserve.