Abstract: In order to realize the efficient recovery and utilization of copper, zinc and sulfur, reduce the metal content of the product, improve the product quality grade, and solve the problems of a copper and zinc sulfide ore in Sichuan, such as complex embedding relationship, uneven particle size distribution, high copper, low zinc and high sulfur ore characteristics, difficult separation of copper, zinc and sulfur in the industrial production site, and abnormal fluctuation of production indicators, this paper has carried out process mineralogy research based on the optimization of product quality plan mineral processing exploration test and flotation index comparison test under different process conditions.The purpose of efficient separation and recovery of copper, zinc and sulfur under low alkalinity conditions is achieved by using copper and zinc high-efficiency collectors DF-201, DF-301 and high-efficiency sulfur inhibitor S601, and using the characteristics of high selectivity of collectors DF-201 and DF-301.Under the condition that the content of -0.074 mm in the first stage of grinding accounts for 65%, the principle process of “preferential floatation of copper-copper tail floatation of zinc-zinc tail floatation of sulfur” is adopted, and the copper flotation operation adopts the closed circuit process of “one roughing, one sweeping and three cleaning”.The copper concentrate grade is 23.17%, zinc content is 1.25%, and copper concentrate recovery rate is 96.08%.The zinc flotation operation adopts the closed circuit process of “one roughing, one sweeping and four cleaning”.The grade of zinc concentrate is 42.20%, the copper content is 0.32%, and the recovery rate of zinc concentrate is 75.25%.The closed circuit process of “one roughing, one scavenging and two cleaning” is adopted for the sulfur flotation operation.The grade of sulfur concentrate is 35.25%, the zinc content is 0.43%, and the recovery rate of sulfur concentrate is 65.00%.The research results in this paper can provide technical reference for the efficient recovery and utilization of the same type of ores.