Abstract: In response to the obvious mutual influence between the central air shaft system and southern air shaft system of Xinqiao Coal Mine and the insufficient ventilation capacity of the southern wing mining area, the basic parameters of the mine ventilation system are measured using the base point method. The current ventilation system and the proposed optimization plan are solved using the loop air volume method and Scott-hensley iteration method for ventilation network calculation. The results of mine ventilation resistance measurement indicate that the central air shaft system and southern air shaft system have the highest resistance consumption in the return air section, which is about 60%; the matching between the air volume and ventilation resistance of the central air shaft system is unreasonable, and the ventilation resistance is too high; the resistance consumption in the public section reaches 36% of the air pressure of the central air shaft fan and 45% of the air pressure of the southern air shaft fan. There is a significant mutual influence between the central air shaft system and the southern air shaft system. Analysis of the solution results of three optimization schemes shows that: in order to meet the air demand of various air consumption points on the south wing, ventilation adjustment facilities can be set up in the ventilation pedestrian alley at the upper entrance of the south wing coal bunker in the short term, so as to control the air volume at 13.33 m³/s; to completely solve the problems of insufficient air volume and high ventilation resistance in the south wing, it is necessary to form a new parallel return air roadway in the south wing.