Abstract: The well pattern layout is one of the most important mining design in the process of in-situ leaching development in sandstone type uranium deposits, which is related to the mine investment, resource recovery rate and service life of mining area. There are many factors affecting the well pattern layout, but there is no consensus on which main factors and the influence size of factors to consider in the design process. According to the research status of well pattern layout, the main influencing factors of well pattern layout are discussed, and the “two-level and multi factor” index system of influencing factors of well pattern layout of in-situ leaching uranium is constructed by using the independent index classification method. In order to compare the relative importance of each index, a judgment matrix is constructed by using analytic hierarchy process, and the importance ranking and corresponding weight values of each index are obtained. Among them, the buried depth, grade, thickness, permeability and continuity of the ore body are the main factors affecting the well pattern layout, and the cumulative frequency of weight is 81.33%. The construction of the index system and the establishment of the evaluation weight provide the necessary basis for the development design and well pattern optimization of sandstone type uranium deposits.