Abstract: The radioactive physical geological data is the core specimen obtained in uranium ore geological exploration, which is very precious and belongs to three major geological data with resulting geological data and original geological data . With the rapid development of nuclear industry geology and mining in China, the growing number of geological prospecting samples lack of unified information management and collection system, which seriously affects the utilization and development of uranium geological information. Therefore, it is urgent to carry out the information construction of radioactive physical geological data management, improve the storage and utilization capacity of radioactive physical geological data, and promote the sustainable development of uranium geological prospecting and economy and society. By applying management information system theory, this paper puts forward the idea of constructing the physical geological data management information system for nuclear industry, which provides a practical solution for realizing the information management of physical geological data.