Abstract: This paper firstly conducts rock mechanics experiments to obtain the main physical and mechanical parameters of three types of rocks. Based on the on-site engineering geological survey results, the classification and evaluation of ore and rock quality are completed, and combines with the actual production situation of the mine, a mining plan for filling medium deep holes is determined; Three mining methods are compared and analyzed, and the downward small segmented efficient ecological mining method with superior indicators is ultimately recommended for the stope. By constructing an engineering geological model and using numerical simulation methods to analyze the stability of the stope structure, it is recommended to adopt a staggered layout of the stope, with a span of 8 m and a height of no more than 12 m, to ensure mining safety. The design adopts an upward fan-shaped medium deep hole, with a blast hole diameter of 65 mm, with a minimum resistance line range of W=1.2-1.5 m, a blast hole spacing of 1.4-1.9 m, and a unit explosive consumption of 0.30-0.45 kg/t. A numerical model of ore and rock is constructed using FLAC^3D. Through simulation, it is determined that the strength of the bottom layer filling body must reach 3.1 MPa, and the strength of the top layer filling body must reach 1.6 MPa. The industrial trial production statistics show that the process parameters determined by the above research results are relatively reasonable, the production efficiency has been increased by 2.5 times, and the mining cost has been reduced by 50%.