Abstract: The key to preventing and controlling coal mine water hazards lies in accurately and efficiently detecting and predicting hidden geological structures. This paper utilizes a combination of time domain electromagnetic method and borehole radar method for comprehensive detection. The one-dimensional inversion of time domain electromagnetic detection results is used to obtain an apparent resistivity profile, which can determine the fluid properties of geological structure anomaly areas. The borehole radar detection method is used to locate geological structure anomaly areas. Taking the 120905 working face of Longfeng Coal Mine in Guizhou as an example, the comprehensive detection method of “time domain electromagnetic+borehole radar” is applied in field experiments to obtain three 3-6 Ω∙ m block shaped low resistance areas and three geological abnormal structures. Different detection parameters are used to comprehensively interpret the same target, proving that the low resistance area is highly consistent with the geological abnormal structure area. The positions and sizes of the three aquifers are delineated, and they are easy to conduct in the subsequent mining process. By combining preliminary geological exploration with later drilling verification, it is proven that the “time domain electromagnetic+borehole radar” comprehensive detection method is accurate in predicting water ahead of time. The research results show that through on-site engineering practice, data collection, data processing, and abnormal area interpretation, it has been proven that the combination of “time domain electromagnetic+borehole radar” detection can complement and verify each other, and comprehensive interpretation can improve accuracy, thereby avoiding the problem of multiple interpretations in geophysical exploration. The “time domain electromagnetic+borehole radar” comprehensive geophysical exploration technology has high accuracy and strong reliability in advance water exploration and prediction in coal mines. Subsequently, it can provide technical references for similar hidden geological structures in Guizhou and provide a basis for the prevention and control of coal mine water hazards.