Abstract: The stability of the surrounding rock of deep roadways is crucial for high production and efficiency of mines. Currently, there are many factors affecting the stability of roadways, such as stress, deformation angles, and the angle between the roadway axis and the lateral pressure coefficient. In order to further investigate other factors affecting the stability of roadways, three factors closely related to the stability of roadways, including the cross-sectional shape, the maximum principal stress, and the angle between the roadway axis and the lateral pressure coefficient, are selected and numerically simulated and analyzed using orthogonal design methods. Based on the experimental results, a sensitivity analysis is conducted on the response characteristics of the roadway to different factors, and the order of factors affecting the response of the surrounding rock of the roadway is studied, providing a scientific basis for the design of the stability of deep high-stress roadways. The results show that the stability of the surrounding rock of the roadway is significantly affected by the cross-sectional shape. The smoother the boundary line of the roadway, the more uniform the stress distribution and the smaller the plastic zone. Through sensitivity analysis, it is found that the cross-sectional shape has a higher impact on the plastic zone and deformation of the surrounding rock of the roadway, while the maximum principal stress, the angle between the roadway axis and the lateral pressure coefficient, and the lateral pressure coefficient have a lower impact on the plastic zone and deformation of the surrounding rock. In contrast, the lateral pressure coefficient has the lowest sensitivity to the behavior of the surrounding rock of the roadway. These research results provide important references for further understanding the stability of the surrounding rock of the roadway, and have practical significance for the optimization of roadway design and support schemes.