Abstract: In order to prevent the occurrence of water inrush disasters during the mining of the 52607 working face in Daliuta Coal Mine, the target of water inrush disasters is determined based on the analysis of spatial distribution location, geological structure conditions, and water hazard. On this basis, according to the limit equilibrium theory, the mechanical model of the advanced mining stress of the coal and rock mass is constructed, the influence characteristics of various factors on the mining stress are analyzed, and the failure depth of the floor rock mass is obtained based on the Mohr-Coulomb failure criterion and yield condition. The results show that the failure depth of the floor in the overlying goaf is about 11 m, connected with the water-conduction fracture zone of the 52607 working face, and is very prone to water inrush disasters. Therefore, the audio frequency electric penetrating technology and the radio wave penetration method are used to detect the hidden dangers of water hazards; the audio frequency electric penetrating technology shows that the anomaly area is mainly distributed near the cutting section of the working face, the radio wave penetration method shows that there is an apparent geological structure in the working face, and the local low field range is the anomaly caused by the exposed fault. The establishment of a flood control wall to prevent surface water from directly communicating with the underground along the water-conducting fracture zone, combining the geophysical prospecting results with the drilling project, and taking the detection of abnormal areas（the cutting section of the working face, the overlying goaf, the 2-2 coal seam burning areas in the middle of the working face, and conveyor gateway） as the critical prevention and control areas, and carrying out detection and drainage in advance, which is conducive to the efficient development of waterproofing and drainage work of the working face, and has essential promotion and application value for the safe mining under the aquifer.