Abstract: The synergy stability of open-pit mine slopes and roadways is a crucial factor affecting safe mining. Conducting research on the synergy stability of mining slopes and roadways is one of the vital tasks to ensure safe construction in mines. Analyzing and demonstrating whether factors such as subsequent mining, engineering mechanics, and water collection impact the deep mining engineering of the Ⅳ and Ⅶ mining groups, in response to the current issue of water accumulation in the open-pit of the Ⅵ mining group in the mining area. A three-dimensional geological model of the open-pit mine is established by 3Dmine, and a risk slope profile is cut and a numerical model is established. Combined with COMSOL Multiphysics multi-field coupling analysis software, the seepage field and stress field of the established profile model are coupled, and the steady-state solution is obtained by finely dividing the grid. The damage area, stress field, and displacement change cloud map of the profile model are obtained. Among them, there is a water accumulation problem in the foundation pit of slope No.5 profile area, and the seepage condition is considered in the solution process. The analysis results show that the damage to the rock mass of the Ⅵ and Ⅶ open-pit slopes has no impact on the underground engineering. The infiltration speed of the water accumulation in the Ⅵ mine pit is distributed between 10⁻⁷ m/s and 10⁻⁶ m/s. Due to the low infiltration speed, the water collection in the Ⅵ mine pit has not significantly affected the stability of the nearby mining engineering. It is recommended to timely drain the water from the Ⅵ mine pit and strengthen the displacement monitoring of the Ⅶ open-pit slope. The research results provide new ideas and references for demonstrating the synergy stability of slopes and roadways.