Abstract: As the single assignment method has a certain bias, it is difficult to take into account the experience of production practice and the intrinsic correlation characteristics of the index parameters, which easily leads to the distortion of the evaluation results. To address this problem, firstly, it analyzes the influencing factors of the water inrush from Ordovician on the bottom plate and the mechanism of each factor and determines the main controlling factors affecting the water inrush from Ordovician. Secondly, the main and objective weights of the main control factors are determined by AHP and CRITIC, and the AHP-CRITIC comprehensive zoning evaluation model of water inrush risk based on the minimum information entropy method is constructed, and the results of the zoning evaluation of the water inrush from Ordovician of the mines are obtained by using the GIS information fusion technology. Finally, based on the zoning evaluation results and the physical exploration results, a water disaster zoning prevention and control program is formulated for the working face, and the working face is divided into a key exploration area, a secondary key exploration area, and a general exploration area, and long-distance directional drilling and conventional drilling are used to carry out exploration and management and supplemental and validation work for different zones, respectively. The results show that the number of water outflow points of the exploratory boreholes, the amount of water outflow from individual boreholes, and the amount of grouting in individual boreholes are relatively high in the hazardous zone, followed by the second key exploratory zone and the least in the general exploratory zone, and the number of water outflow points of the boreholes and their planar distribution locations have a better correspondence with the results of the model partitioning, which verifies the accuracy of the evaluation model. It provides a method for the zoning evaluation and prevention of water inrush from Ordovician under similar conditions.