Abstract: Lead-zinc ore is often processed using high alkali rapid flotation technology for ore dressing. The water quality characteristics of the ore dressing wastewater generated during the ore dressing process are complex, with high concentrations of COD, heavy metals, solid suspended solids, and salt, as well as large pH value fluctuations. The difficulty of wastewater treatment is high, posing a huge threat to the environment and human health. The conventional methods for treating ore dressing wastewater are difficult to achieve the best wastewater treatment effect, and the effect is unstable, which cannot guarantee the standard discharge of ore dressing wastewater. In order to achieve stable and standard discharge of lead-zinc ore dressing wastewater treatment, this paper first conducts research on the water quality characteristics of a certain lead-zinc ore dressing wastewater. Based on the characteristics of the wastewater, the “biochemical+advanced oxidation” process is adopted to optimize and verify various process parameters such as biochemical reaction time, different advanced oxidation methods, and reagent dosage, and calculate the operating cost of wastewater treatment. The experimental results show that the “biochemical+ozone catalytic oxidation” process can achieve stable effluent of lead-zinc dressing wastewater and meet the special emission limit requirements for water pollutants in the “Emission Standard of Pollutants for Lead and Zinc Industry”（GB 25466—2010）. The optimal process parameters are the anaerobic aerobic reaction time of SBR process is 2 h∶10 h, the volume of ozone catalyst is 30% of the reactor volume, the ozone dosage is 90 mg/L, and the direct operating ton of water cost is 3 yuan. This process can effectively solve the problem of meeting the standard for the treatment of lead-zinc ore beneficiation wastewater, and provide reference for the treatment of beneficiation wastewater in similar lead-zinc mines.