Abstract: The mineral composition of a gold mine in Liaoning Province is complex, mainly containing metallic minerals such as pyrite, pyrrhotite, galena, chalcopyrite and sphalerite, mainly containing nonmetallic minerals such as sillimanite, biotite, muscovite, quartz, plagioclase, microcline and a small amount of graphite. Pyrite, the main metal mineral, is distributed along rock cracks in vein shape, some of which are disseminated and some of which are wrapped with chalcopyrite, and the symbiotic relationship between the minerals is close. The grades of gold and silver in the ore are 1.98 g/t and 7.40 g/t, respectively. However, no gold and silver minerals are found in the rock and ore identification under the microscope, which indicates that the disseminated particle size of gold and silver is extremely fine or exists as lattice gold. In order to realize the effective recovery of gold, flotation and non-cyanide leaching are used for experimental research respectively. By flotation test, under the conditions of coarse grinding fineness of −0.074 mm, content of 71.2%, sodium carbonate dosage of 1 000 g/t and collector dosage of 60 g/t, the recovery rate of gold is 62.15%, and the recovery rate of gold after fine grinding is still below 70%, which can be inferred that the relationship between gold minerals and sulfur minerals is not very close. The non-cyanide non-toxic leaching agent DBH is used for leaching test. Under the conditions of grinding fineness of −0.074 mm, calcium oxide content of 95.3%, calcium oxide dosage of 2.00 kg/t and DBH dosage of 4.0 kg/t, and leaching time of 24 h, the leaching rates of gold and silver are 90.26% and 40.88% respectively, and the recovery effect is good. Lead salt and oxidant are used as leaching AIDS to carry out leaching experiments, and the leaching rates of gold and silver increase to 91.16% and 52.35% respectively. It can be seen that the non-cyanide leaching process has a good effect on the recovery of gold and silver in the ore, and the recovery of silver in the ore can be significantly improved by using lead salts and oxidants, which provides some reference for the non-cyanide leaching technology of gold-bearing minerals.