Abstract: Affected by the thrust structure, the strata in the open-pit mining area are complex and the geological conditions of the slopes in different areas are different. In addition, under the thrust action, the strata are highly variable, making it difficult to clearly define the specific distribution characteristics of the bottom strata. When designing the slope angle, it is not conducive to determine the safe slope angle, and it also brings great difficulties to the boundary. In order to ensure the efficient development of resources, fully utilize the stable slope angle of the geological strata, and reduce the amount of open-pit mining and stripping, this paper takes the open-pit mine of the main ore body in Kambove under the geological conditions of the thrust structure as the background, considers three factors: mining depth, groundwater level, and the width of the fault hanging platform, designs different combinations of factors, and considers the working conditions separately to study the slope stability under complex geological conditions of the thrust structure. The results show that in the single factor working condition of mining depth, the slope safety factor decreases with the increase of mining depth, and the rate of decrease gradually slows down. When the mining depth exceeds 210 m, due to the funnel-shaped shape of the open-pit mining pit, as the depth increases, the exposed area of the deep slope per unit height decreases, and the slope body of the lower slope plays a restraining role in deformation. Under the single factor conditions of groundwater and the width of the fault hanging wall, the stability of the slope decreases with the deterioration of the working conditions. Under the influence of dual or multiple factors, and influenced by the superposition of various factors, the greater the mining depth and groundwater level, or the smaller the width of the fault hanging wall, the greater the deformation at the foot of the slope and overall. Finally, by simulating the stability of the optimized full mining area slope, it is found that when the reduction coefficient is 1.5, there is no large-scale displacement of the slope, and the slope stability is good.