Abstract: Under the framework of three-dimensional territorial spatial planning, conducting spatial guarantee research for mineral resource exploration and development holds significant practical value in enhancing national energy and mineral resource security. Addressing the unique characteristics of mineral resource distribution, this study employs policy analysis, literature review, and systematic analysis to analyze the necessity of vertical spatial integration in planning management, and illustrate spatial relationships among underground resource stratum, surface substrate layer, planning zoning layer, and regulatory control layer. Based on a systematic review of existing institutional arrangements related to spatial layout coordination of mineral resource exploration and development, it identifies key challenges that still need to be addressed to advance the three-dimensional integrated utilization of mineral resource exploration and development spaces. These challenges include how to prioritize the multiple strategic objectives; how to resolve coordination challenges between mineral resource planning and territorial spatial planning; how to resolve the complex issues of ownership and compensation related to mineral resource exploration; how to solve common issues in the three-dimensional composite utilization of territorial space, such as stratified spatial delineation and property rights registration, and so on. To address these challenges, this study proposes a spatial-temporal solution pathway for mineral resource exploration and development spatial allocation from three perspectives: priority coordination of strategic objectives, full life-cycle management of resource spaces, and revitalizing existing reserves to ensure incremental growth. By integrating six operational mechanisms: ends-driven planning, dynamic entry-exit mechanism, shared benefit mechanisms, moderate storage management, enhanced regulatory oversight, and diversified monetization strategies, a territorial spatial-temporal management model is constructed. This model achieves full life-cycle management of mineral development and other resource utilization, offering actionable recommendations to safeguard exploration and development spaces.