Abstract: Tailings are the waste discharged by the ore dressing plant under specific economic and technical conditions after grinding the ore finely and selecting the useful components, which is the largest industrial solid waste in China. The massive accumulation of tailings not only creates safety hazards but also brings problems such as occupying land and polluting land and water bodies. The use of tailings for mine filling is an effective way to realize the disposal of tailings in bulk quantity. High sulfur tailing sand generally refers to tailing sand with a sulfur content greater than 8%, and the utilization rate of high sulfur tailings sand in mine filling is relatively low due to the sulfate generated from the oxidation of high sulfur tailings sand, which will have a destructive effect on the hardening process of cement when it reaches a certain concentration. Finding ways to inhibit the oxidation of high sulfur tailing sand is one of the ways to reduce the environmental pollution of high sulfur tailing sand and improve the utilization rate of high sulfur tailing sand filling. In this paper, by carrying out the oxidation experiment of high sulfur tailings sand, it has explored and studied the influence of the reducing property of water quenching blast furnace slag on the oxidation process of high sulfur tailings sand, and by observing the experimental results and combining the theoretical analysis and the research results of other scholars, it can draw the following conclusions: ① high sulfur tailing sand can undergo oxidation reaction in water, and the main reaction process is that sulfides such as magnetite pyrite and the dissolved oxygen in the water react with the water to generate sulfate root and hydrogen ions. The mine ore can have oxidation reactions in water and hydrogen ions. ② Slag powder has an inhibitory effect on the oxidation process of high sulfur tailings, which can significantly slow down the oxidation rate of high sulfur tailings in water. ③ Slag powder has reducing property, the source of reducing property is the reducing atmosphere in the blast furnace, and the material bearer is the sulfur in the low valence state. ④ The reason that slag powder inhibits the oxidation rate of high sulfur tailings sand is that the sulfur in the slag in the low valence state reacts preferentially with the dissolved oxygen in the water, which reduces the oxidation rate of sulfide in the high sulfur tailings sand.