Abstract: The height of open-pit mine slopes increases continuously with mining production, which also brings about slope stability problem. Conducting slope stability analysis and safety evaluation is a necessary task for the design of safety facilities in new open-pit mine projects. Taking the slope of a proposed open-pit mine in Xinjiang as the research object, a potential risk analysis of the slope is conducted through on-site investigation. The potential failure modes of single step and local combination steps are determined to mainly include plane sliding, wedge sliding, and bending tilting. Multiple limit equilibrium methods are used to carry out slope stability calculations. By calculating the slope stability coefficient under load combinations such as self-weight, blasting vibration, and earthquake, the safety status of the slope is evaluated, and the optimal slope angle is determined. The finite difference method is used for three-dimensional numerical simulation, displacement field, stress field, and plastic zone distribution analysis are conducted on the deformation and failure characteristics during slope excavation, which provides slope risk control suggestions for the safe operation of open-pit mine slopes. The project research can provide reference for the design of safety facilities in similar new open-pit mining projects.