Abstract: A total of 11 elements, including Au, Ag, Cu, Pb, Zn, Mo, W, Bi, Sb, As and Hg, were selected as indicator elements. A 1∶10000 soil geochemical survey was carried out in Lizigou mining area. The iterative elimination method was used to calculate the element geochemical characteristic parameters in the mining area, delineate the single element geochemical anomalies and comprehensive anomalies, and provide geochemical information for further prospecting. The scale index method was used to evaluate the comprehensive anomaly sequence, and the expected anomaly was selected for engineering verification. A gold ore body was found in the deep part of the ore bearing structural belt. The prospecting prospect of the mining area is analyzed by comparing with the geochemical characteristics of the soil in the adjacent mining area.