Abstract: The Central America Region is abundant in mineral resources. The study on the mineral resources endowment, exploration & development situation and cooperation prospect of the Central America Region has important directive significance for Chinese enterprises to carry out mining investment in Central America Region. The research shows that the Central America Region has experienced strong orogeny and magmatic activity in the Mesozoic and Cenozoic, and formed large-scale Central American volcanic with superior ore-forming geological conditions. Copper, gold, nickel and silver are very abundant in the Central America Region. The metallogenic epochs of the main mineral resources of the Central American Region are the Mesozoic and Cenozoic. The Republic of Nicaragua is the country which has the largest mineral resources exploration investment in the Central American Region. Gold has the largest exploration investment among all the kinds of mineral resources in the Central American Region. The exploration investment of mineral resources of the Central American Region is mainly from intermediate mining companies. Mining companies from Canada and the United States are the leaders in mineral resources exploration and development in the Central America Region. The production of copper and nickel occupies a certain position in the world. The main producer of copper is the Republic of Panama, and the main producer of nickel is the Republic of Guatemala. The mineral resources exploration targets of the Central America Region in the future are the copper, gold, nickel and silver which are formed in the Mesozoic and Cenozoic. In the future, China has broad prospects for mining cooperation with the Central America Region.