Abstract: Based on the analysis of the dissolution and migration mechanism of radionuclides, an architecture of nuclide blocking system in the associated radioactive solid waste landfill facility is proposed, and the nuclear in the construction of the associated radioactive solid waste landfill facility is introduced from three aspects: waste pretreatment, engineering barrier and natural barrier. The framework of the prime retardation system has certain reference significance for the consultation and design of the associated radioactive solid waste landfill facility.