Abstract: Collophane is an important strategic mineral resource in China. The majority of China’s phosphate resources are mainly low-grade and medium-grade collophane, which are difficult to beneficiate. In order to improve the flotation efficiency and reduce the flotation cost of collophane, this paper introduces the global distribution characteristics and resource categories of collophane resources, summarizes the flotation process and research progress of various methods and agents, as well as the current problems of collophane flotation, summarizes the main development and research directions of collophane flotation, and provides reference for the development and utilization of collophane resources in China. The main flotation methods include positive flotation, reverse flotation, positive-reverse flotation, reverse-positive flotation, double reverse flotation and combined beneficiation. Positive flotation is mainly suitable for the situation that the floatability of gangue and collophane is different. Reverse flotation mainly treats collophane with high calcium and magnesium content, which is widely used. Other flotation processes target specific compositions of collophane. The combined beneficiation method has cost and environmental advantages, but the gravity separation effect is not good. The research progress of pharmaceuticals mainly reviews the latest research progress from the aspects of regulators, flocculants, foaming agents, inhibitors and collectors. New modifiers are being explored. The non-ionic flocculant effect of flocculant is good, but the relevant research needs to be strengthened. The research on alcohols, ether esters and new foaming agents in foaming agents needs to be deepened. In terms of inhibitors, new bio-based inhibitors have great potential, and the research of combination inhibitors and new organic inhibitors has become a trend. Among the collectors, fatty acids are modified and combined to improve their performance, but complex minerals still need to be optimized, amines overcome defects through research and development and modification, and the separation effect of amphoteric collectors is good, but the cost is high, and the development of new amphoteric collectors is the future direction.