Abstract: The Huangmaoshan tailings in Gejiu Area contain 0.18% tin with characteristically fine particle sizes, where the −0.019 mm fraction accounts for a significant 45.31% of the total. The coarse fraction exhibits poor mineral liberation, making neither standalone flotation nor gravity separation processes effective for efficient recovery. To achieve tin recovery from Huangmaoshan tailings, this paper develops a novel process based on their key characteristics: poor mineral liberation, fine particle size distribution, and high slime content, it develops a combined gravity-flotation process featuring “multi-stage cyclone desliming and classification-coarse-grained regrinding and gravity separation-fine-grained desulfurization flotation”. The multi-stage cyclone pre-desliming can effectively reject 42.15% of slimes in advance. The tailings after desliming are reclassified, with the +0.045 mm coarse fraction is reground and separated by shaking table. A gravity tin concentrate with a grade of 3.87% and an operation recovery of 64.29% is obtained. For the fine particle size fraction of −0.045 mm, a closed-circuit process of flotation desulfurization and tin flotation with one roughing, two cleaning and two scavenging operations is adopted, and tin concentrate with a grade of 5.14 % and an operation recovery rate of 59.76% is obtained. The comprehensive tin concentrate with grade of 4.48% and recovery of 51.01% is obtained in the whole process test. This technology has broken through the technical bottleneck that has prevented the efficient and comprehensive utilization of the tailings resources in Huangmaoshan for more than 40 years, and provided reliable technical support for the green utilization of similar tin tailings resources.