Abstract: The mining disturbance of underground working face in coal mine has a significant influence on the advance support of fully mechanized gob-side entry. Therefore, a numerical model is established based on FLAC^3D software, and the stress wave conforming to the mining disturbance of shearer is input to simulate the mining of working face. The numerical simulation results of monitoring points on the goaf side and the solid coal side of the roof under the coupling support strategy of horizontal and vertical combined unequal strength are solved. The dynamic responses of displacement and stress are compared and analyzed. The results show that the stress wave formed by the mining disturbance of working face decreases with the increase of distance, and the mining disturbance of working face is less affected at about 20 m from the end of working face. The vertical displacement and stress of the monitoring points on the goaf side change more, and the horizontal displacement and stress of the monitoring points on the solid coal side change more, and the fluctuation is within a reasonable range, which verifies the feasibility of the horizontal and vertical combined unequal strength coupling support strategy to control the roadway roof under the mining disturbance condition of the working face. The research results can provide reference for the stability control of gob-side entry under mining disturbance.