Abstract: In order to solve the problem that CO gas in the tail gas of rubber-tyred vehicles in coal mines endangers the health of workers. In this study, the CO toxic gas is purified in the high gravity field, and the cuprous chloride ammonia solution is used as the absorption liquid. The effects of four factors, including the concentration of the absorption liquid, the rotor speed of the high gravity machine, the gas flow rate and the liquid flow rate, on the CO gas removal rate and the total volume mass transfer coefficient of the gas phase are investigated, and the response surface analysis diagram of the influence of four factors on the CO removal rate is made. The results show that the CO gas removal rate increases with the increase of absorption liquid concentration, rotor speed and liquid flow rate, and decreases with the increase of gas flow rate. The total mass transfer coefficient of gas phase increases with the increase of rotor speed, liquid flow rate, gas flow rate and absorption liquid concentration. The optimum conditions of the experiment are as follows: the concentration of absorption liquid is 0.2%, the rotor speed is 1 280 r/min, the gas flow rate is 20 m³/h, the liquid flow rate is 4.5 L/min, the CO gas removal rate is 83.33%, and the total volume mass transfer coefficient of gas phase is 0.51 kmol/m³·s. This study provides a theoretical basis for solving the problem of CO gas in the tail gas of rubber-tyred vehicles in coal mines.