Abstract: The Luishia Copper-Cobalt Mining Area in Congo（DRC） contains a large number of talc layers, which makes the slope stability problem more complicated. The characteristics of talc in Luishia Copper-Cobalt Mining Area and its influence on slope stability are analyzed in detail. The mechanical parameters of rock mass are estimated by Hoek-Brown criterion, and the slope stability under talc factor is discussed by sensitivity analysis method. It is found that talc has the greatest influence on slope stability. Finally, the treatment measures of “cutting slope and reducing load + laying anti-seepage film on surface + hanging net spray” are put forward, and the effect of slope treatment is verified by finite element strength reduction method. This study can not only provide technical support for the Luishia Mining Area, but also provide reference for the slope stability problems that are common in the development of global mineral resources.