Abstract: In this study, the limit balance analysis of slope stability and the landslide comprehensive treatment of open-pit mine, the slope stability is evaluated on the deformation area of 42 m platform of Xibang 1 060-660 exploration lines in a mine area. The slope shape is drawn by AUTOCAD software, and imported into MIDAS software for numerical calculation model establishment and grid division, to simulate the slope safety factor, displacement, stress and strain analysis under the influence of dead-weight and groundwater under natural working conditions. The results show that the slope is in an unstable state, with different degrees of movement, and a risk of shear damage. Based on these findings, a comprehensive treatment scheme of slope cutting and load reduction and engineering reinforcement is proposed to improve the stability of the slope. The research provides a scientific basis for the stability evaluation and treatment of open-pit mine, and is of great significance to ensure the safety of mine production.