Abstract: The new back analysis method of physics and mechanics parameters of surrounding rock was established by uniform design, calculus of differences and fuzzy artificial neural networks in this paper. According to uniform design, different physics and mechanics parameters were chosen. Using FLAC program to calculate, the related analytical samples of neural networks were given. Structure and training parameters of networks were optimized. Training was conduced by fuzzy artificial neural networks. Physics and mechanics parameters of surrounding rock of Hanjialing tunnel were back analyzed by training results and the on-the-spot survey data of every measured section.