Abstract: With the improvement of the people's awareness of environmental protection,green development for beneficiation has become increasingly intense.Either from the limitations of source,polluting to the environment,or from the flotation efficiency,traditional mineral processing reagents are difficult to meet the requirements.However,because microbial mineral processing agent is wide source,non-toxic,good selectivity and so on.It has received more and more attention in recent years and it is expected that it will be able to replace or partially replace chemical mineral processing agent.Based on the results of relevant research at home and abroad,this article reviews the application of the microbe and microbial metabolites in flocculant and flotation,and describes the mechanism of microbial dressing agent,and explains the development trend of microbial beneficiation agent.