Abstract: According to depositing condition of ore-body and stability of ore-body and wall-rock, 31^# ore-body up level 475m of Nanping Ta and Nb Mine is grouped into 13 mining segments in this paper. Mining methods and structural parameters is proposed. Stability and possible failure mode of stope ceiling and pillar is predicted by means of expert system. On the basis of above, structural parameters of stope and mining sequence is optimized by numerical simulation method. Thereby, the structural parameters of stope and mining sequence of 31^#ore-body is determined. Finally, layout of stoping segment which is suitable to 31^#ore-body up level 475m is put forward.