Abstract: From the analysis of the chemical composition of six kind of mineral dusts and the changes of number of colony, pH, glucose (GLU) and electrolyte after the dusts acted with S. epidernidis. Compared the chemical composition and physics properities of dusts on experiment index bacteria. And then through SEM analysis, studied the bacterial form and interface act in the action process of dusts and bacteria. The results show that all kinds of mineral dusts have different degree effects on experiment bacteria. The dust of DJ-20# and DJ -22# which contain Ca²⁺ or Mg²⁺ have obvious function of promote bacterial growth, but DJ-5# dust has some bacteriostatic. So we can say that the effect of industrial and mineral dusts to the body normal flora have correlation with dust's chemical composition and physics properities. Proper mineral dusts which contain Ca²⁺ or Mg²⁺ can promote the bacterial growth.