Abstract: According to the coarse size of Pb-Sb mineral seriesly pulluted by reagents and fine slime without pulled by reagents for the mill,the new technology was used to treat the slime and coarse Pb-Sb mineral, and Zn rough concentrate was reground and separation again in the presence of new depressant Y1 to depress sulphur minerals.Pb recovery of 81.52% and Zn recovery of 82.59% were obtained by using this new technology.