Abstract: According to the research on flotation reagent in niobium ore,action mechanism of collector with niobium ore is reviewed.Due to the existing problems on niobium ore collector,the performance which new kinds of collector should possess is put forward.The research progress of regulator in niobium ore is summarized,and the idea is pointed out that the effective inhibitor on gangue minerals will be the key in the research of regulator of niobium ore.To the flotation on niobium ore,usually the traditional chemical reagents were used to change the floatability of useful minerals and gangue minerals,but the results were not perfect.Finally,through analyzing the characteristics of niobium minerals and their associated minerals,a new idea of niobium ore pretreatment with biology is proposed,in which the properties of useful minerals and gangue minerals will be changed.So,the difference on floatability among minerals will be expanded,and efficient recovery of niobium minerals will be achieved.