Abstract: The application and technology used in the construction of environment friendly uranium mine by means of CO₂ and O₂ in-situ leach mining are discussed，including the key techniques such as the non-polluted groundwater circulation，the leaching area controlling as well as volume reduced of industrial waste water(precipitation liquor recycling，reverse osmosis treatment of transformation waste water).The favorable results are obtained in industrial test and production，the concentration of superficial radioactive contamination of radon and its daughters is controlled to meet the state standard，therefore，making the technology of CO₂ and O₂ in-situ leaching of uranium a green and environment protection mining method.