Abstract: Based on the damage characteristics of skip loading chamber of Majialiang coal mine, the paper analyzed the mechanism of the method combined grouting anchor cable with concrete structure reinforcement applied to control the deformation and stress of the wall rock, and believed that grouting anchor cable can improve the structure and strength of rock and concrete structure reinforcement can improve the bearing capacity of the support. At the same time, the paper proposed a reinforcement scheme combined grouting anchor cable with concrete structure reinforcement, and the reinforcement scheme was demonstrated by the method of numerical simulation and displacement monitoring. The results showed that the reinforcement scheme combined grouting anchor cable with concrete structure reinforcement evidently reduced the stress and deformation of the chamber, and kept the chamber in safely used.