Abstract: Based on the data processing function of the GPS Pinnacle software, through the research on Design of GPS monitoring control network of the open-pit slope in shuichang iron mine, RMS of GPS Baseline Vectors, GPS Network Synchronous Loop Disclosure, GPS Network Asynchronous, and Normal gauss distribution on Residual Histogram is done, Design of slope monitoring network in shuichang iron mine is optimized, and the reliability of the GPS monitoring network is improved.