Abstract: Research coal-bed methane mining technology and comprehensive utilization of coal-bed methane in Guizhou, In this paper, first of all, it is conducive to the province to prevent gas accidents, followed by the exhaust gas into a useful resource will help ease tensions in Guizhou province of energy, optimizing energy structure, reduce greenhouse gas emissions, reducing air pollution and to ensure coal mine safety production, once again the development and utilization of coalbed methane in the economic benefits are also considerable.