Abstract: Different from in plain area, plateau mines are mainly characterized by rarefied air, insufficient oxygen and changing natural ventilation which directly lead to low working efficiency of equipment and serious pollution of tunnels. Consequently, it is quite difficult to carry out the network calculation and optimization of mine ventilation system. To solve this problem, we made an optimum ventilation design by taking advantage of analytic hierarchy process model and Ventsim, a 3D ventilation simulation software. At first, based on key ventilation parameters which are modified judging by plateau adaptability, a 3D visual model of ventilating system and a network platform of real-time solution are built up. Next, four feasible ventilation schemes are proposed according to the requirements of the mine's ventilation system. Furthermore, we get not only the ventilating performances but also the 3D simulation interface for each scheme with the help of the Ventsim platform. Finally, taken availability, economic rationality, stability, safe reliability, plateau applicability and other factors all into consideration, an analytic hierarchy process is adopted to select the scheme which is most suitable for the case. The optimized ventilation system can not only guarantee a sound ventilation effect, but also achieve cost savings, so that it can provide reasonable support for ventilation construction and management of the mine.