Abstract: This research is focused on a low-grade oxidized lead-zinc ore from Yunnan with high mud,complex intergrowth correlation and dispersed.By comparing different scheme, use sodium sulfide as the activator of lead ore and butyl-xanthate as collector preferential revover lead;then use octadecyl-amine as collector of the tailing, Pb concentrate contains Pb 50.60% with a recovery of 77.65%,and the Zn concentrate contains Zn 40.39% with a recovery of 75.85%.