Abstract: This paper is based on multispectral remote sensing data, using MPH mineralization faint information quantificationally extracting technology. Gold mine remote sensing mineralization faint information is carried out quantificationally extracting in vegetation and land cover seriously and geology setting composite southeast Guizhou province about 2.86 thousand square km, and the extracted remote sensing mineralization faint information zone is coincident with the known gold mineral deposit dot. Based on remote sensing geological interpretation in detail, the relationship between remote sensing geological characters and gold mine are analyzed systemically. Using all kinds of remote sensing structure information and remote sensing mineralization faint information synthetically, combining existed geophysical and geochemical exploration data, remote sensing finding mine model is built, five gold mine prospecting areas are delineted, furthermore significant finding mine target areas is confirmed. It has obtained good finding mine effect through survey validating in the field.