Abstract: On the basis of experience and lessons of in-situ leaching mining of paleochannel-type sandstone-hosted uranium deposits in Kazakhstan, china and other countries, through analyzing the main difference between interlayer oxidation-type sandstone-hosted uranium deposit and paleochannel-type sandstone-hosted uranium deposit, points out the inhomogeneity of geological and hydrogeological condition and mineralization characteristics of paleochannel-type sandstone-hosted uranium deposits are the biggest factors which influences economical feasibility of in-situ leachin mining uranium, and puts forward rational organization of productive exploration and mine development are only method to solve the problem. Further, combined with the technological characteristics of in-situ leaching uranium mining, preliminarily discussed the content, method and fundamental principle of productive exploration and mine development in order to provide reference for mining this type of deposits by in-situ leaching method.