Abstract: It has been proved that the industrial innovation ecosystem is the key to realize the mineral resource-based city transformation at home and abroad.By this,taking the coal-to chemical industrial cluster of Zaozhuang city for example,the concept of cluster ecosystem on resource city innovation was advanced,and it network structure model was developed accordingly.The model including two layers and four groups,is an interactive network dominated with enterprise,university,research institution,government and intermediaries,etc.According to interactions among main communities of the ecosystem and the urban transformation practices,some running modes were established and a series of safeguards were proposed to promote the system running effectively.