Abstract: Deep ore has become one of the important object of mineral exploration in China. The research revealed that There are plenty of mineral resources in the depth of mine in China. Based on the analysis of the definition of deep ore, prospecting potential of the depth of mine in China, the technical route, challenges and the research situation of metallogenic theory of metallogenic system, the second enrichment belt and comprehensive geological studies and technology and method of geochemistrical and geophysical survey of deep ore prospecting, some suggestions such as the conversion of prospecting thinking,strengthen the research of metallogenic theory and research and development the new technology and method of exploration are proposed.